Analysis of the Results on Perioperative Blood Loss after a Total Knee Arthroplasty Employing Tranexamic Acid before or after Inflating the Tourniquet

Some solutions, as the administration of antifibrinolytic drugs (tranexamic acid), have been proposed to reduce the bleeding on a TKR surgery and to decrease the number of transfusions. Hyperfibrinolysis is considered being the major cause of postoperative bleeding after TKA surgery [10-14], the fibrinolytic system is activated in the first hours after surgery increasing the postoperative bleeding after remove the pneumatic tourniquet [15-17]. Tranexamic acid (TXA, trnas-4aminomethyl cyclohexane carboxylic acid), is a synthetic reversible inhibitor of fibrinolysis, that competitively blocks a lysine binding site of plasminogen [18]. It has been used during more than 20 years in cardiac surgery, urology, genecology, liver transplants, etc. This Abstract